Now in its Fourth Edition, An Introduction to Medical Statistics continues to be a "must-have" textbook for anyone who needs a clear logical guide to the subject. Written in an easy-to-understand style and packed with real life examples, the text clearly explains the statistical principlesused in the medical literature. Taking readers through the common statistical methods seen in published research and guidelines, the text focuses on how to interpret and analyse statistics for clinical practice. Using extracts from real studies, the author illustrates how data can be employed correctly and incorrectly in medicalresearch helping readers to evaluate the statistics they encounter and appropriately implement findings in clinical practice. End of chapter exercises, case studies and multiple choice questions help readers to apply their learning and develop their own interpretative skills. This thoroughly revised edition includes new chapters on meta-analysis, missing data, and survival analysis.
Now in its Fourth Edition, An Introduction to Medical Statistics continues to be a 'must-have' textbook for anyone who needs a clear logical guide to the subject. Written in an easy-to-understand style and packed with real life examples, the text clearly explains the statistical principles used in the medical literature. Taking readers through the common statistical methods seen in published research and guidelines, the text focuses on how to interpret and analyse statistics for clinical practice. Using extracts from real studies, the author illustrates how data can be employed correctly and incorrectly in medical research helping readers to evaluate the statistics they encounter and appropriately implement findings in clinical practice. End of chapter exercises, case studies and multiple choice questions help readers to apply their learning and develop their own interpretative skills. This thoroughly revised edition includes new chapters on meta-analysis, missing data, and survival analysis.
Correctly understanding and using medical statistics is a key skill for all medical students and health professionals. In an informal and friendly style, Medical Statistics from Scratch provides a practical foundation for everyone whose first interest is probably not medical statistics. Keeping the level of mathematics to a minimum, it clearly illustrates statistical concepts and practice with numerous real world examples and cases drawn from current medical literature. This fully revised and updated third edition includes new material on: missing data, random allocation and concealment of data intra-class correlation coefficient effect modification and interaction diagnostic testing and the ROC curve standardisation Medical Statistics from Scratch is an ideal learning partner for all medical students and health professionals needing an accessible introduction, or a friendly refresher, to the fundamentals of medical statistics.
Most medical researchers, whether clinical or non-clinical, receive some background in statistics as undergraduates. However, it is most often brief, a long time ago, and largely forgotten by the time it is needed. Furthermore, many introductory texts fall short of adequately explaining the underlying concepts of statistics, and often are divorced from the reality of conducting and assessing medical research. Practical Statistics for Medical Research is a problem-based text for medical researchers, medical students, and others in the medical arena who need to use statistics but have no specialized mathematics background. The author draws on twenty years of experience as a consulting medical statistician to provide clear explanations to key statistical concepts, with a firm emphasis on practical aspects of designing and analyzing medical research. The text gives special attention to the presentation and interpretation of results and the many real problems that arise in medical research.
Provides students and practitioners with a clear, concise introduction to the statistics they will come across in their regular reading of clinical papers. Written by three experts with wide teaching and consulting experience, Medical Statistics: A Textbook for the Health Sciences, Fourth Edition: Assumes no prior knowledge of statistics Covers all essential statistical methods Completely revised, updated and expanded Includes numerous examples and exercises on the interpretation of the statistics in papers published in medical journals From the reviews of the previous edition: "The book has several excellent features: it is written by statisticians, is.... well presented, is well referenced.... and is short." THE LANCET "Many statisticians are concerned at the generally poor standard of statistics in papers published in medical journals. Perhaps this could be remedied if more research workers would spare a few hours to read through Campbell and Machin's book." BRITISH MEDICAL JOURNAL "... a simple, interesting and insightful introduction to medical statistics... highly recommended." STATISTICAL METHODS IN MEDICAL RESEARCH "Campbell and Machin found the golden mean... this book can be recommended for all students and all medical researchers." ISCB NEWSLETTER
As many medical and healthcare researchers have a love-hate relationship with statistics, this practical reference book may make all the difference. It takes examples, mainly from the authors' own research, to explain how to make sense of statistics, turn statistical computer results into coherent information, and help decide which pieces of information to report and how to present them. Presenting Medical Statistics includes a wide range of statistical analyses, and all the statistical methods are illustrated using real data. Labelled figures show the Stata and SPSS commands needed to obtain the analyses, with indications of which information should be extracted from the output for reporting. The relevant results are then presented as for a report or journal article, to illustrate the principles of good presentation. The reader is taken through the various stages of the research process, from the initial research proposal, ethical approval and data analysis, to reporting on and publishing the findings. There are even extensive references for those who wish to find out more about the statistical methods. This is a must for anyone working with statistics in the medical profession.
This book deals with statistics in medicine in a simple way. The text is supported by abundant examples from medical data. This book aims to explain and simplify the process of data presentation. Further aspects addressed include how to design and conduct clinical trials, and how to write journal articles.
Statistical Questions in Evidence-based Medicine is a companion volume to the new edition of An Introduction to Medical Statistics and includes questions and answers which are complementary to the textbook. This new book takes a practical approach that develops an understanding of statistics and suggests appropriate questions to ask about research methods, figures and conclusions and whether they are evidence based. The book is a model of clarity and common sense in what is frequently an unnecessarily obscure area of science. It looks at the application of and provides a critique of statistics, encouraging an evidence-based approached to medical statistics. Through the critical evaulation of the published medical literature, the text will enable both students and researchers to understand the appropriate use of descriptive and inferential statistics in study design and when writing papers. The reproduction of short excerpts of material from published papers or summaries of their results are included and they are considered in a question and answer format. The reader can either read through the series of cases and follow through worked examples or work through the book themselves as a series of exercises. The questions are clearly graded, through the use of icons, in terms of difficulty into standard and postgraduate levels. This book will prove invaluable to students, medical researchers and doctors alike.
An introductory guide to clinical research, written specifically for junior doctors by a team of highly experienced authors. This practical book covers all areas that a junior doctor will need to consider, including funding, study design, ethics, data analysis, disseminating findings, and furthering one's research career.
The book aims to provide both comprehensive reviews of the classical methods and an introduction to new developments in medical statistics. The topics range from meta analysis, clinical trial design, causal inference, personalized medicine to machine learning and next generation sequence analysis. Since the publication of the first edition, there have been tremendous advances in biostatistics and bioinformatics. The new edition tries to cover as many important emerging areas and reflect as much progress as possible. Many distinguished scholars, who greatly advanced their research areas in statistical methodology as well as practical applications, also have revised several chapters with relevant updates and written new ones from scratch. The new edition has been divided into four sections, including, Statistical Methods in Medicine and Epidemiology, Statistical Methods in Clinical Trials, Statistical Genetics, and General Methods. To reflect the rise of modern statistical genetics as one of the most fertile research areas since the publication of the first edition, the brand new section on Statistical Genetics includes entirely new chapters reflecting the state of the art in the field. Although tightly related, all the book chapters are self-contained and can be read independently. The book chapters intend to provide a convenient launch pad for readers interested in learning a specific topic, applying the related statistical methods in their scientific research and seeking the newest references for in-depth research. Contents:Statistics in Medicine and Epidemiology:History of Statistical Thinking in Medicine (Tar Timothy Chen)Describing Data, Modeling Variation, and Statistical Practice (Hongyan Du and Ming T Tan)Covariate-Specific and Covariate-Adjusted Predictive Values of Prognostic Biomarkers with Survival Outcome (Yunbei Ma, Xiao-Hua Zhou and Kwun Chuen (Gary) Chan)Statistical Methods for Personalized Medicine (Lu Tian and Xiaoguang Zhao)Statistics Used in Quality Control, Quality Assurance, and Quality Improvement in Radiological Studies (Ying Lu and Shoujun Zhao)Applications of Statistical Methods in Medical Imaging (Jesse S Jin)Cost-Effectiveness Analysis and Evidence-Based Medicine (Jianli Li)Quality of Life: Issues Concerning Assessment and Analysis (Jiqian Fang and Yuantao Hao)Meta-Analysis (Xuyu Zhou, Jiqian Fang, Chuanhua Yu, Zongli Xu, Lu Tian, and Ying Lu)Statistical Models and Methods in Infectious Diseases (Hulin Wu and Shoujun Zhao)Special Models for Sampling Survey (Sujuan Gao)The Use of Capture–Recapture Methodology in Epidemiological Surveillance and Ecological Surveys (Anne Chao, T C Hsieh and Hsin-Chou Yang)Statistical Methods in the Effective Evaluation of Mass Screening for Diseases (Qing Liu)Statistics in Clinical Trials:Statistics in Biopharmaceutical Research and Development (Shein-Chung Chow and Annpey Pong)Statistics in Pharmacology and Pre-Clinical Studies (Tze Leung Lai, Mei-Chiung Shin and Guangrui Zhu)Statistics in Toxicology (James J Chen)Dose-Response Modeling and Benchmark Doses in Health Risk Assessment (Yiliang Zhu)Some Fundamental Statistical Issues and Methodologies in Confirmatory Trials (George Y H Chi, Haiyan Xu and Qing Liu)Surrogates for Qualitative Evaluation of Treatment Effects (Zhi Geng)Adaptive Trial Design in Clinical Research (Annpey Pong and Shein-Chung Chow)Statistics in the Research of Traditional Chinese Medicine (Danhui Yi and Yang Li)Statistical Genetics:Sparse Segment Identifications with Applications to DNA Copy Number Variation Analysis (X Jessie Jeng, T Tony Cai and Hongzhe Li)Statistical Methods for Design and Analysis of Linkage Studies (Qizhai Li, Hong Qin, Zhaohai Li, and Gang Zheng)Transcriptome Analysis Using Next-Generation Sequencing (Jingyi Jessica Li, Haiyan Huang, Minping Qian and Xuegong Zhang)Genetic Structure of Human Population (Hua Tang and Kun Tang)Data Integration Methods in Genome Wide Association Studies (Ning Sun and Hongyu Zhao)Causal Inference (Zhi Geng)General Methods:Survival Analysis (D Y Lin)Nonparametric Regression Models for the Analysis of Longitudinal Data (Colin O Wu, Xin Tian, Kai F Yu, and Mi-Xia Wu)Local Modeling: Density Estimation and Nonparametric Regression (Jianqing Fan and Runze Li)Statistical Methods for Dependent Data (Feng Chen)Bayesian Methods (Ming-Hui Chen and Keying Ye)Valid Prior-Free Probabilistic Inference and Its Applications in Medical Statistics (Duncan Ermini Leaf, Hyokun Yun, and Chuanhai Liu)Stochastic Processes and Their Applications in Medical Science (Caixia Li and Jiqian Fang)Interpolation of Missing Values and Adjustment of Moving Holiday Effect in Time Series (Zhang Jin-Xin, Zhang Xi, Xue Yun-Lian, Li Ji-Bin and Huang Bo)Tree-based Methods (Heping Zhang)Introduction to Artificial Neural Networks (Xia Jielai, Jiang Hongwei, and Tang Qiyi) Readership: Biostatisticians, applied statisticians, medical researchers and clinicians, biopharmaceutical researchers, public health epidemiologists, biometricians and applied mathematicians. Key Features: The book covers very broad topics in medical statistics The book covers both most recent developments as well as classical work of the selected areas The book chapter is written by the experts in the field and illustrated with real life examplesKeywords:Medicine;Statistics;Epidemiology;Genomics;Clinical Trials;Bioinformatics;Machine Learning;Statistical Theory;Public HealthReviews: Review of the First Edition: “Overall the book covers a wide variety of applications. Each method is presented in sufficient depth to allow the reader to understand when the method(s) can be used … this book would be a useful resource for any practitioner in medical research.” Statistical Methods in Medical Research
The majority of medical research involves quantitative methods and so it is essential to be able to understand and interpret statistics. This book shows readers how to develop the skills required to critically appraise research evidence effectively, and how to conduct research and communicate their findings.
The fifth revised edition of this highly successful book presents the most extensive enhancement since Using and Understanding Medical Statistics was first published 30 years ago. Without question, the single greatest change has been the inclusion of source code, together with selected output, for the award-winning, open-source, statistical package known as R. This innovation has enabled the authors to de-emphasize formulae and calculations, and let software do all of the ‘heavy lifting’. This edition also introduces readers to several graphical statistical tools, such as Q-Q plots to check normality, residual plots for multiple regression models, funnel plots to detect publication bias in a meta-analysis and Bland-Altman plots for assessing agreement in clinical measurements. New examples that better serve the expository goals have been added to a half-dozen chapters. In addition, there are new sections describing exact confidence bands for the Kaplan-Meier estimator, as well as negative binomial and zero-inflated Poisson regression models for over-dispersed count data. The end result is not only an excellent introduction to medical statistics, but also an invaluable reference for every discerning reader of medical research literature.
This textbook provides an introduction to the free software Python and its use for statistical data analysis. It covers common statistical tests for continuous, discrete and categorical data, as well as linear regression analysis and topics from survival analysis and Bayesian statistics. Working code and data for Python solutions for each test, together with easy-to-follow Python examples, can be reproduced by the reader and reinforce their immediate understanding of the topic. With recent advances in the Python ecosystem, Python has become a popular language for scientific computing, offering a powerful environment for statistical data analysis and an interesting alternative to R. The book is intended for master and PhD students, mainly from the life and medical sciences, with a basic knowledge of statistics. As it also provides some statistics background, the book can be used by anyone who wants to perform a statistical data analysis.
Designed to assist those working in health research, An Introduction to Stata for Health Researchers, explains how to maximize the versatile Strata program for data management, statistical analysis, and graphics for research. The first nine chapters are devoted to becoming familiar with Stata and the essentials of effective data management. The text is also a valuable companion reference for more advanced users. It covers a host of useful applications for health researchers including the analysis of stratified data via epitab and regression models; linear, logistic, and Poisson regression; survival analysis including Cox regression, standardized rates, and correlation/ROC analysis of measurements.
Taking a practical approach and supported by global examples from all areas of health, the new edition of this popular and highly commended textbook has been updated to reflect current epidemiological thinking and teaching. Based on feedback from teachers and students, material has been reordered to better suit courses and reflect the underlying logic and purpose of epidemiology. • Provides students with a rounded picture of the field by emphasizing the commonalities across different areas of epidemiology, including clinical epidemiology, and highlighting the key role of epidemiology in public health • Avoids complex mathematics by restricting this to optional material, thereby keeping the book accessible to students from non-quantitative backgrounds • Integrated and supplementary questions help students to reinforce concepts • A wealth of online material is available at, including additional questions, advanced material for key concepts, recommendations for further reading, links to useful websites and slides for teaching, supporting both students and teachers.
Medical Statistics Made Easy 3e scores 99/100 and 5 stars on Doody's (Sept 2014)! Here's what the reviewer said: "This is a practical guide to the use of statistics in medical literature and their application in clinical practice. The numerous examples help make the conceptualization of complex ideas easy. It is a great resource for healthcare students and clinicians in the field." Medical Statistics Made Easy has been a perennial bestseller since it was first published in 2003 (#1 bestseller in medical statistics on Amazon). It is widely recommend on a variety of courses and programmes, from undergraduate medicine, through to professional medical qualifications. It is a book of key statistics principles for anyone studying or working in medicine and healthcare who needs a basic overview of the subject. Using a consistent format, the authors describe the most common statistical methods in turn and then rate them on how difficult they are to understand and how common they are. The worked examples that demonstrate the statistical method in action have been updated to include current articles from the medical literature and now feature a much wider range of medical journals. This new third edition continues with the same structure as the previous editions and also includes a new section on statistical process controls. From reviews of the second edition: "We would recommend this book as an introduction into medical statistics before plunging into the deep 'statistical' waters! It gives confidence to the reader in taking up the challenge of understanding statistics and [being] able to apply knowledge in analysing medical literature." Stefanie Zhao Lin Lip & Louise Murchison, Scottish Medical Journal, June 2010 "If ever there was a book that completely lived up to its title, this is it... The whole way in which the authors have written this book is commendable; the chapters are succinct, easy to follow and a pleasure to read...Is it value for money? ? a definite yes even at twice the price. Of course I never exaggerate but if you breathe, you should own this book!" Ian Pearce, Urology News, June 2010
Statistical methods are a key tool for all scientists working with data, but learning the basic mathematical skills can be one of the most challenging components of a biologist's training. This accessible book provides a contemporary introduction to the classical techniques and modern extensions of linear model analysis: one of the most useful approaches in the analysis of scientific data in the life and environmental sciences. It emphasizes an estimation-based approach that accounts for recent criticisms of the over-use of probability values, and introduces alternative approaches using information criteria. Statistics are introduced through worked analyses performed in R, the free open source programming language for statistics and graphics, which is rapidly becoming the standard software in many areas of science and technology. These analyses use real data sets from ecology, evolutionary biology and environmental science, and the data sets and R scripts are available as support material. The book's structure and user friendly style stem from the author's 20 years of experience teaching statistics to life and environmental scientists at both the undergraduate and graduate levels. The New Statistics with R is suitable for senior undergraduate and graduate students, professional researchers, and practitioners in the fields of ecology, evolution, environmental studies, and computational biology.
This comprehensive workbook contains a variety of self-assessment methods that allow readers to test their statistical knowledge, put it into practice, and apply it in a medical context, while also providing guidance when critically appraising published literature. It is designed to support the best-selling third edition of Medical Statistics at a Glance, to which it is fully cross-referenced, but may be used independently of it. Ideal for medical students, junior doctors, researchers and anyone working in the biomedical and pharmaceutical disciplines who wants to feel more confident in basic medical statistics, the title includes: • Over 80 MCQs, each testing knowledge of a single statistical concept or aspect of study interpretation • 29 structured questions to explore in greater depth several statistical techniques or principles, including the choice of appropriate statistical analyses and the interpretation of study findings • Templates for the appraisal of clinical trials and observational studies, plus full appraisals of two published papers to demonstrate the use of these templates in practice • Detailed step-by-step analyses of two substantial data sets (also available at to demonstrate the application of statistical procedures to real-life research Medical Statistics at a Glance Workbook is the ideal resource to test statistical knowledge and improve analytical and interpretational skills. Additional resources are available at, including: • Excel datasets to accompany the data analysis section • Downloadable PDFs of two templates for critical appraisal • Links to online further reading • Supplementary MCQs

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