Examining the implications and practical implementation of multi-disciplinary International Conference on Harmonization (ICH) topics, this book gives an integrated view of how the guidelines inform drug development strategic planning and decision-making. • Addresses a consistent need for interpretation, training, and implementation examples of ICH guidelines via case studies • Offers a primary reference point for practitioners addressing the dual challenge of interpretation and practical implementation of ICH guidelines • Uses case studies to help readers understand and apply ICH guidelines • Provides valuable insights into guidelines development, with chapters by authors involved in generating or with experience implementing the guidelines • Includes coverage of stability testing, analytical method validation, impurities, biotechnology drugs and products, and good manufacturing practice (GMP)
Der Megatrend der 5:2-Diäten sorgt in England bereits ordentlich für Wirbel. "The Fast Diet" ist das Buch, das den Hype auslöste - das Original. Das Konzept ist bestechend einfach: Man legt zwei Fastentage in der Woche ein, an denen die Kalorienzufuhr heruntergefahren wird. An den restlichen fünf Tagen isst man ganz normal. Die Ergebnisse sind erstaunlich: Die Kilos purzeln, durch die gesunde Lebensweise wird das Risiko von Diabetes, Herzerkrankungen und Krebs verringert. Eine Diät, wie sie sich jeder wünscht, der abnehmen möchte: simpel, fundiert, effektiv und gesund!
Der stumme Frühling erschien erstmals 1962. Der Titel bezieht sich auf das eingangs erzählte Märchen von der blühenden Stadt, in der sich eine seltsame, schleichende Seuche ausbreitet … Das spannend geschriebene Sachbuch wirkte bei seinem Erscheinen wie ein Alarmsignal und avancierte rasch zur Bibel der damals entstehendenÖkologie-Bewegung. ZumerstenMal wurde hier in eindringlichem Appell die Fragwürdigkeit des chemischen Pflanzenschutzes dargelegt. An einer Fülle von Tatsachen machte Rachel Carson seine schädlichen Auswirkungen auf die Natur und die Menschen deutlich. Ihre Warnungen haben seither nichts von ihrer Aktualität verloren.
Das Buch gibt eine umfassende Einführung in moderne angewandte Kryptografie. Es behandelt nahezu alle kryptografischen Verfahren mit praktischer Relevanz. Es werden symmetrische Verfahren (DES, AES, PRESENT, Stromchiffren), asymmetrische Verfahren (RSA, Diffie-Hellmann, elliptische Kurven) sowie digitale Signaturen, Hash-Funktionen, Message Authentication Codes sowie Schlüsselaustauschprotokolle vorgestellt. Für alle Krypto-Verfahren werden aktuelle Sicherheitseinschätzungen und Implementierungseigenschaften beschrieben.
Knowledge Translation in Health Care is a practicalintroduction to knowledge translation for everyone working andlearning within health policy and funding agencies, and asresearchers, clinicians and trainees. Using everyday examples, itexplains how to use research findings to improve health care inreal life. This new second edition defines the principles and practice ofknowledge translation and outlines strategies for successfulknowledge translation in practice and policy making. It includesrelevant real world examples and cases of knowledge translation inaction that are accessible and relevant for all stakeholdersincluding clinicians, health policy makers, administrators,managers, researchers, clinicians and trainees. From an international expert editor and contributor team, and fullyrevised to reflect current practice and latest developments withinthe field, Knowledge Translation in Health Care is thepractical guide for all health policy makers and researchers,clinicians, trainee clinicians, medical students and otherhealthcare professionals seeking to improve healthcarepractice.
Using Evidence to Guide Nursing Practice 2e is an invaluable ‘how-to’ guide for students and experienced nurses alike. Emphasis is placed on how to develop an evidence-based culture in the workplace, support clinicians to make decisions using the best available evidence and translating this evidence into practice. This new edition is divided into five concise sections which guide readers from an examination of evidence, to developing a workplace culture that supports Evidence-Based Practice. It demonstrates how to locate and appraise evidence, how to evaluate practice and finally how to translate evidence into practice with a new applied case study included. includes two new chapters; ‘Locating and appraising the evidence’ and ‘ Evidence to inform nursing practice: An applied approach’ highlights Evidence-based Practice (EBP) initiatives and demonstrates how to develop an evidence-based culture in the workplace includes Step-by-step guides to undertaking a systematic review, a clinical audit and a program evaluation each chapter will have contributions from experienced academics and clinicians across Australia so as to ensure health industry relevance and academic rigour are addressed
As the definitive reference for clinical chemistry, Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 5th Edition offers the most current and authoritative guidance on selecting, performing, and evaluating results of new and established laboratory tests. Up-to-date encyclopedic coverage details everything you need to know, including: analytical criteria for the medical usefulness of laboratory procedures; new approaches for establishing reference ranges; variables that affect tests and results; the impact of modern analytical tools on lab management and costs; and applications of statistical methods. In addition to updated content throughout, this two-color edition also features a new chapter on hemostasis and the latest advances in molecular diagnostics. Section on Molecular Diagnostics and Genetics contains nine expanded chapters that focus on emerging issues and techniques, written by experts in field, including Y.M. Dennis Lo, Rossa W.K. Chiu, Carl Wittwer, Noriko Kusukawa, Cindy Vnencak-Jones, Thomas Williams, Victor Weedn, Malek Kamoun, Howard Baum, Angela Caliendo, Aaron Bossler, Gwendolyn McMillin, and Kojo S.J. Elenitoba-Johnson. Highly-respected author team includes three editors who are well known in the clinical chemistry world. Reference values in the appendix give you one location for comparing and evaluating test results. NEW! Two-color design throughout highlights important features, illustrations, and content for a quick reference. NEW! Chapter on hemostasis provides you with all the information you need to accurately conduct this type of clinical testing. NEW! Six associate editors, Ann Gronowski, W. Greg Miller, Michael Oellerich, Francois Rousseau, Mitchell Scott, and Karl Voelkerding, lend even more expertise and insight to the reference. NEW! Reorganized chapters ensure that only the most current information is included.
Dieses Buch richtet sich an Manager und Unternehmer, die ber die konomisierung ihrer IT nachdenken m ssen. Und an Leser, die mehr ber die Cloud wissen, aber keine Spezialisten werden wollen. Das vorliegende Buch widmet sich ebenso umfassend wie fundiert den technischen, rechtlichen, steuerlichen, betriebswirtschaftlichen und kologischen Aspekten des Cloud Computing, dazu werden praxisrelevante Vorschl ge zur Anbieterauswahl und Zertifizierung gemacht sowie konkrete Checklisten zur Verf gung gestellt.
Supported by over 90 illustrations, this unique book provides a detailed examination of the subject, focusing on the use of voice, data, and video systems for public safety and emergency response. This practical resource makes in-depth recommendations spanning technical, planning, and procedural approaches to provide efficient public safety response performance. You find covered the many approaches used to achieve interoperability, including a synopsis of the enabling technologies and systems intended to provide radio interoperability. Featuring specific examples nationwide, the book takes you from strategy to proper implementation, using enterprise architecture, systems engineering, and systems integration planning.

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