Designed to provide a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries, this book describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. It describes hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." Second Edition highlights: • Reflects the current thinking in chemical process R&D for small molecules • Retains similar structure and orientation to the first edition. • Contains approx. 85% new material • Primarily new examples (work-up and prospective considerations for pilot plant and manufacturing scale-up) • Some new/expanded topics (e.g. green chemistry, genotoxins, enzymatic processes) • Replaces the first edition, although the first edition contains useful older examples that readers may refer to Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules" Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more Presents guidelines for implementing and troubleshooting processes
Handbook of Synthetic Organic Chemistry, Second Edition updates and expands the author’s popular 2007 work, Synthetic Organic Chemist’s Companion. This new handbook provides valuable, practical guidance; incorporates corrections, and includes coverage on important topics, such as lyophylization, crystallization, precipitation, HPLC detectors, gases, and microwave reactions. The book maintains the useful organization of the author’s earlier work, beginning with a basic overview and walking through every practical step of the process of organic synthesis, from reagents, solvents, and temperature control, to documentation, implementation, purification, and analytical methods for the product. From planning and setting up reactions, to recording them, the book provides insight and valuable guidance into every step of the process. Practical guidance for planning, working up, documenting, analyzing, and improving reactions in synthetic organic chemistry
This book brings together the chemical strategies used in the optimisation of organic reactions and processes, and highlights the practical and technological options available. This book offers: an encyclopedic treatment of organic chemistry from an industrial, process research and development, and manufacturing point of view plenty of examples to illustrate the scope and limitation of the strategies a comprehensive index organised by topic, reaction type, and reagent an extensive literature survey. This is an essential and comprehensive guide for experienced practitioners of chemical process research and development, fresh recruits to chemical industry R&D divisions, and academics who are interested in interacting with the chemical industry, optimising their synthetic strategies, and enriching the field of atom economy.
Wilhelm Ostwald: Lebenslinien. Eine Selbstbiographie Erstdruck: Berlin (Klasing) 1926/1927. Vollständige Neuausgabe. Herausgegeben von Karl-Maria Guth. Berlin 2013. Textgrundlage ist die Ausgabe: Ostwald, Wilhelm: Lebenslinien. Eine Selbstbiographie, 3 Teile, Berlin: Klasing, 1926/1927. Die Paginierung obiger Ausgabe wird in dieser Neuausgabe als Marginalie zeilengenau mitgeführt. Umschlaggestaltung von Thomas Schultz-Overhage unter Verwendung des Bildes: Wilhelm Ostwald (1903). Gesetzt aus Minion Pro, 11 pt. Über den Autor: Neben dessen Gründer Ernst Haeckel war der Freimaurer und Chemie-Nobelpreisträger Wilhelm Ostwald einer der führenden Köpfe des Deutschen Monistenbundes, der eine wissenschaftlich begründbare Weltanschauung nach dem Prinzip der Einheit von Natur und Geist vertrat und dabei christlicher Dogmatik widersprach. Er schlug unter dem Namen »Weltdeutsch« ein vereinfachtes Deutsch als internationale Plansprache vor und setzte sich für ein Weltgeld ein. Nach Differenzen mit der Universität Leipzig legte er seinen Lehrstuhl nieder und lebte als Privatforscher bis zu seinem Lebensende 1932 auf seinem Landsitz in Großbothen.
The Practice of Medicinal Chemistry fills a gap in the list of available medicinal chemistry literature. It is a single-volume source on the practical aspects of medicinal chemistry. Considered ""the Bible"" by medicinal chemists, the book emphasizes the methods that chemists use to conduct their research and design new drug entities. It serves as a practical handbook about the drug discovery process, from conception of the molecules to drug production. The first part of the book covers the background of the subject matter, which includes the definition and history of medicinal chemistry, the measurement of biological activities, and the main phases of drug activity. The second part of the book presents the road to discovering a new lead compound and creating a working hypothesis. The main parts of the book discuss the optimization of the lead compound in terms of potency, selectivity, and safety. The Practice of Medicinal Chemistry can be considered a ""first-read"" or ""bedside book"" for readers who are embarking on a career in medicinal chemistry. NEW TO THIS EDITION: * Focus on chemoinformatics and drug discovery * Enhanced pedagogical features * New chapters including: - Drug absorption and transport - Multi-target drugs * Updates on hot new areas: NEW! Drug discovery and the latest techniques NEW! How potential drugs can move through the drug discovery/ development phases more quickly NEW! Chemoinformatics
Nach diesem Buch mit Vorschriften fur die Herstellung einfacher organischer Praparate haben Generationen von Chemikern die Synthesemethoden der organischen Chemie gelernt. Diese Vorschriften veralten nicht."Prof. Dr. Ralf Steudel, TU Berlin
May 11-13, 2017 Amsterdam, Nehterlands Key Topics : Elementary concepts of organic chemistry, Organometallic compounds, Bioorganic chemistry, Carbohydrates and phenols, Stereochemistry, Analytical techniques in organic chemistry, Carboxylic acids and its derivatives, Chemical bonding, Cheminformatics, Green and environmental chemistry, Polymers and monomers, Bio-chemistry and agricultural chemistry, Catalysis of organic reactions, Physical organic chemistry, Natural product chemistry,
With roughly 5500 references, this book may be considered more of a treatise than a mere introduction to green chemistry. Using an unconventional approach, the author provides a broad but thorough review of the subject, covering traditional green chemistry topics such as catalysis, benign solvents, and alternative feedstocks before moving on to less frequently covered topics such as chemistry of longer wear and population and the environmental chemistry. Topics such as these highlight the importance of chemistry to everyday life and demonstrate the real benefits that wider exploitation of green chemistry can have for society.
Endlich gibt es ein weiterführendes Lehrbuch der Organischen Chemie in deutscher Sprache! Es wird die Studenten auf den Gebieten Reaktionsmechanismen, Stereochemie und insbesondere Organische Synthese bis zum Diplom begleiten, und darüber hinaus ist es ein äußerst nützliches Nachschlagewerk auch für Diplomanden und Doktoranden. Die deutsche Ausgabe wurde gegenüber dem Original nochmals erweitert und aktualisiert. Erste Dozentenstimmen: 'Die erste deutsche Ausgabe des Carey/Sundberg erfüllt alle Erwartungen an ein modernes Lehrbuch der Organischen Chemie.' - 'Es ist zur Zeit das beste Lehrbuch der Organischen Chemie und unentbehrlich für fortgeschrittene Studenten, Diplomanden und Doktoranden.' - 'Endlich! Ich empfehle dieses Buch bereits seit Jahren fortgeschrittenen Studenten.' - 'Es ist bezeichnend, daß es immer besonders motivierte und leistungsstarke Studenten waren, die mich fragten, ob ich ihnen den Carey/Sundberg empfehlen kann. Ich kann es.' - 'Endlich wird es ein ausgewogenes Lehrbuch zur Organischen Chemie für Fortgeschrittene in deutscher Sprache geben. Die Kompetenz der Herausgeber bürgt für hohen Standard.'
With the global population projected to reach 9 billion by theyear 2050, the need for nations to secure food supplies for theirpopulations has never been more pressing. Finding better supplychain solutions is an essential part of achieving a secure andsustainable diet for a rapidly increasing population. We are now ina position, through methods including life cycle assessment (LCA),carbon footprinting and other tools, to accurately measure andassess our use – or misuse – of natural resources,including food. The impact of new technologies and managementsystems can therefore improve efficiencies and find new ways toreduce waste. Global Food Security and Supply provides robust, succinctinformation for people who want to understand how the global foodsystem works. The book demonstrates the specific tools availablefor understanding how food supply works, addresses the challengesfacing a secure and safe global food supply, and helps readers toappreciate how these challenges might be overcome. This book is a concise and accessible text that focuses onrecent data and findings from a range of internationalcollaborations and studies. The author provides both asnapshot of global food supply and security today, and a projectionof where these issues may lead us in the future. This book willtherefore be of particular interest to food policy leaders,commercial managers in the food industry, and researchers andstudents seeking a better understanding of a rapidly evolvingtopic.
Taste is the number one driving force in the decision to purchase a food product and food consumption is the most critical function for living organisms to obtain the energy and resources essential to their vitality. Flavor and aroma are therefore universally important concepts: intrinsic to human well-being and pleasure, and of huge significance for the multi-trillion dollar global food business. How Flavor Works: the Science of Taste and Aroma offers a fascinating and accessible primer on the concepts of flavor science for all who have an interest in food and related topics. Professionals and students of food science and technology who do not already specialize in flavor science will find it a valuable reference on a topic crucial to how consumers perceive and enjoy food products. In this regard, it will also be of interest to product developers, marketers and food processors. Other readers with a professional (eg culinary and food service) or personal interest in food will also find the book interesting as it provides a user-friendly account of the mechanisms of flavor and aroma which will provide new insights into their craft.
Das Buch "Färbung von Lebensmitteln, Arzneimitteln, Kosmetika" wendet sich an Praktiker in der Lebensmittel-, Arzneimittel- und Kosmetikindustrie. Beschrieben werden anwendungstechnische Hinweise, einfache analytische Arbeitsmethoden sowie Informationen über die Zulässigkeit der Färbemittel in D, der EU und den wichtigsten Staaten außerhalb der EU. Von besonders großem Nutzen für die Praxis ist der sehr umfangreiche Block an Datenblättern der Färbemittel für Lebensmittel, Arzneimittel und Kosmetika! Die Datenblätter sind nach der Colour Indexnummer bzw. bei Färbemitteln in alphabetischer Reihenfolge geordnet.
In anschaulicher Form – unterstützt durch zahlreiche Abbildungen – wird in diesem aktualisierten Lehrbuch in die Methode der Kristallstrukturbestimmung eingeführt. Die kristallographischen Grundlagen und einzelne praktische Schritte der modernen Kristallstrukturbestimmung werden verständlich und nachvollziehbar erklärt.
Wirkt sofort! Dieser Taschenatlas hilft. Beschwerden der Verwirrung und Überforderung werden sofort gemildert und weichen dem Gefühl des Verstehens und Begreifens. Die Wirkstoffe Visualisierung und Kompaktheit sind in großen Mengen aktiv. - Über 170 brillante Infografiken illustrieren die Pharmakologie und erleichtern dir den Zugang zu pharmakologischen Sachverhalten. Die kompakten Lerneinheiten eignen sich als Ergänzung zu einem Lehrbuch, zum Vertiefen und Wiederholen. Alle relevanten Informationen zu Wirkstoffgruppen kannst du rasch und gut verständlich nachlesen. Das sinnvolle arzneimitteltherapeutische Vorgehen bei wichtigen Erkrankungen kompakt und auf dem aktuellen Stand. Arzneimittel-Konvertierungslisten helfen dir auf der Suche nach dem Wirkstoff- oder Handelsnamen. Dank Daumenregister und Farbleitsystem kannst du dich schnell orientieren. Du verstehst Zusammenhänge und schaust über den ein oder anderen Tellerrand.
A practical guide for ensuring a defect-free coating and drying process For professionals in the coating and drying industry, the world is a demanding place. New, technically complex products such as fuel cell membranes, thin film batteries, solar cells, and RFID chips require coatings of extreme precision. With the bar raised so high, understanding how to troubleshoot and eliminate defects on a coating line is an essential skill for all personnel. Coating and Drying Defects, Second Edition provides manufacturing and quality control personnel, equipment operators and supervisors, and plant engineers and scientists with the full complement of proven tools and techniques for detecting, defining, and eliminating coating defects and operating problems, and for ensuring that they do not recur. Updating the valuable contents of the first edition, this practical Second Edition: Describes all major processes for coating and drying of continuous film on sheets or webs Covers technologies that have been recently developed to prevent defect formation and improve operating procedures Provides a rational framework within which to assess and analyze virtually any defect that may arise Offers step-by-step guidelines for conducting every phase of the troubleshooting process, including defect prevention Going beyond simply describing a disparate set of troubleshooting techniques, this unique guide arms readers with a systematic, nonmathematical methodology encompassing the entire coating operation, becoming an indispensable resource for manufacturing and quality-control personnel as well as plant engineers, polymer scientists, surface scientists, organic chemists, and coating scientists.
Process Intensification: Engineering for Efficiency, Sustainability and Flexibility is the first book to provide a practical working guide to understanding process intensification (PI) and developing successful PI solutions and applications in chemical process, civil, environmental, energy, pharmaceutical, biological, and biochemical systems. Process intensification is a chemical and process design approach that leads to substantially smaller, cleaner, safer, and more energy efficient process technology. It improves process flexibility, product quality, speed to market and inherent safety, with a reduced environmental footprint. This book represents a valuable resource for engineers working with leading-edge process technologies, and those involved research and development of chemical, process, environmental, pharmaceutical, and bioscience systems. No other reference covers both the technology and application of PI, addressing fundamentals, industry applications, and including a development and implementation guide Covers hot and high growth topics, including emission prevention, sustainable design, and pinch analysis World-class authors: Colin Ramshaw pioneered PI at ICI and is widely credited as the father of the technology

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